Leukotriene D: a slow reacting substance from rat basophilic leukemia cells. | Zendy

Lars Örning | Zendy; Sven Hammarström | Zendy; Bengt Samuelsson | Zendy

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Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.

Author(s) -

Lars Örning,

Sven Hammarström,

Bengt Samuelsson

Publication year - 1980

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.77.4.2014

Subject(s) - leukotriene , chemistry , ionophore , leukotriene d4 , leukotriene c4 , guinea pig , stereochemistry , leukotriene b4 , arachidonic acid , moiety , basophilic , biochemistry , peptide , enzyme , biology , endocrinology , receptor , immunology , inflammation , membrane , medicine , pathology , asthma , antagonist

A slow reacting substance produced by rat basophilic leukemia cells, treated with ionophore A23187, was characterized by spectroscopic methods, enzymatic conversions, and chemical degradations as 5-hydroxy-6-S-cysteinylglycyl 7,9,11,14-eicosatetraenoic acid (leukotriene D). gamma-Glutamyltranspeptidase [gamma-glutamyltransferase; (5-glutamyl)-peptide: amino-acid 5-glutamyltransferase, EC 2.3.2.2] converted leukotriene C to a product identical to leukotriene D. This suggests that the stereochemistry of the arachidonyl moiety of leukotrienes C and D is the same [5(S)-6(R)-7,9-trans-11,14-cis]. Leukotriene D induces a faster contraction and, on a molar basis, is more potent than leukotriene C in the isolated guinea pig ileum bioassay.

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