Choline accumulation by photoreceptor cells of the rabbit retina. | Zendy

Richard H. Masland | Zendy; John W. Mills | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Choline accumulation by photoreceptor cells of the rabbit retina.

Author(s) -

Richard H. Masland,

John W. Mills

Publication year - 1980

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.77.3.1671

Subject(s) - choline , phosphorylcholine , retina , acetylcholine , extracellular , phospholipid , microbiology and biotechnology , biochemistry , cell membrane , biophysics , chemistry , membrane , biology , neuroscience , endocrinology

Photoreceptor cells of the rabbit retina accumulate choline from the extracellular environment by an overall process that has a high affinity for choline. These cells do not synthesize acetylcholine; instead, the choline taken up is incorporated into phosphorylcholine and eventually phospholipid. A mechanism for efficient choline accumulation is presumably concomitant to the photoreceptor cell's synthesis of large amounts of membrane for outer segment membrane renewal. Its existence in the photoreceptor cell supports previous evidence that high-affinity choline uptake is not confined to neurons that release acetylcholine, but may be present wherever large amounts of choline are required.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research