Autoantibody to centromere (kinetochore) in scleroderma sera. | Zendy

Y Möroi | Zendy; Carol Peebles | Zendy; Marvin J. Fritzler | Zendy; James C. Steigerwald | Zendy; Eng M. Tan | Zendy

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Autoantibody to centromere (kinetochore) in scleroderma sera.

Author(s) -

Y Möroi,

Carol Peebles,

Marvin J. Fritzler,

James C. Steigerwald,

Eng M. Tan

Publication year - 1980

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.77.3.1627

Subject(s) - autoantibody , centromere , sclerodactyly , biology , antigen , crest syndrome , scleroderma (fungus) , immunology , microbiology and biotechnology , antibody , chromosome , pathology , genetics , calcinosis , medicine , autoimmune disease , connective tissue disease , calcification , inoculation , gene

Sera from patients with scleroderma contained several autoantibodies to nuclear antigens which were distinguished by different patterns of nuclear immunofluorescence staining. One of these autoantibodies reacted with centromeric regions of chromosomes. In chromosome spreads, the staining appeared as two small spheres at the centromere, resembling kinetochores. The antigenic determinant appeared to be a protein or polypeptide tightly bound to DNA. The autoantibody was reactive with centromeres of cells derived from humans, mice, and Chinese hamsters. The autoantibody was present in high frequency in the calcinosis/Raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) of scleroderma.

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