Identification of an adhesion factor for chondrocytes. | Zendy

A. Tyl Hewitt | Zendy; Hynda K. Kleinman | Zendy; John P. Pennypacker | Zendy; George R. Martin | Zendy

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Identification of an adhesion factor for chondrocytes.

Author(s) -

A. Tyl Hewitt,

Hynda K. Kleinman,

John P. Pennypacker,

George R. Martin

Publication year - 1980

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.77.1.385

Subject(s) - fibronectin , chondrocyte , trypsin , chemistry , cartilage , adhesion , microbiology and biotechnology , fibroblast , biochemistry , in vitro , extracellular matrix , biology , anatomy , enzyme , organic chemistry

The attachment of chondrocytes to collagen substrates is stimulated by serum but not by fibronectin. The active material in serum was partially purified and was shown to be a protein by its sensitivity to trypsin and heat and its chromatographic properties. This factor, which we have named chondronectin, is distinct from fibronectin and does not stimulate fibroblast attachment. Because material with similar attachment-enhancing activity is produced by chondrocytes and is extractable from cartilage, chondronectin may be a chondrocyte-specific attachment protein.

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