Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides. | Zendy

L. B. TOWNSEND | Zendy; Karl H. Schram | Zendy; J. Beránek | Zendy

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Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides.

Author(s) -

L. B. TOWNSEND,

Karl H. Schram,

J. Beránek

Publication year - 1979

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.76.8.4075

Subject(s) - complement (music) , chemistry , triangulation , feature (linguistics) , receptor , leukemia , computational biology , biochemistry , stereochemistry , biology , immunology , mathematics , linguistics , geometry , philosophy , complementation , gene , phenotype

The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a "common receptor-complement feature" has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the "receptor-complement feature" as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.

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