Open AccessEvaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides.
Author(s) -
Leroy B. Townsend,
Karl H. Schram,
Jaroslav Beránek
Publication year - 1979
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.76.8.4075
Subject(s) - complement (music) , chemistry , triangulation , feature (linguistics) , receptor , leukemia , computational biology , biochemistry , stereochemistry , biology , immunology , mathematics , linguistics , geometry , philosophy , complementation , gene , phenotype
The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a "common receptor-complement feature" has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the "receptor-complement feature" as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.