Interrupting the early region of polyoma virus DNA enhances tumorigenicity. | Zendy

Mark A. Israel | Zendy; Daniel T. Simmons | Zendy; S L Hourihan | Zendy; Wallace P. Rowe | Zendy; Miguel Martı́n | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Interrupting the early region of polyoma virus DNA enhances tumorigenicity.

Author(s) -

Mark A. Israel,

Daniel T. Simmons,

S L Hourihan,

Wallace P. Rowe,

Miguel Martı́n

Publication year - 1979

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.76.8.3713

Subject(s) - virus , biology , restriction enzyme , dna , polyoma virus , virology , microbiology and biotechnology , cleavage (geology) , antigen , genome , carcinogenesis , gene , genetics , paleontology , fracture (geology)

The tumorigenicity of DNA from polyoma virus after cleavage with a variety of restriction enzymes was evaluated in suckling hamsters. Cleavage with enzymes that interrupt the region of the genome coding for the large tumor (T) antigen of polyoma virus markedly enhanced the tumorigenicity above that observed with DNA I of the virus. Cell lines established in vitro from tumors induced by polyoma virions, polyoma virus DNA I, or polyoma virus DNA that had been cleaved with restriction endonucleases in the early region all contain the polyoma virus middle and small T antigens but not the large T antigen of polyoma virus is not required for maintenance of the transformed state and probably not for initiation of tumorigenesis by viral DNA.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research