Open AccessWater permeability changes studied by 17O nuclear magnetic resonance during differentiation of Friend leukemia cells.
Author(s) -
N. Haran,
Zvi Malik,
Aviva Lapidot
Publication year - 1979
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.76.7.3363
Subject(s) - permeability (electromagnetism) , dimethyl sulfoxide , membrane , chemistry , biophysics , doubling time , membrane permeability , leukemia , nuclear magnetic resonance , biochemistry , biology , in vitro , immunology , organic chemistry , physics
Water permeability of Friend leukemia cells was studied by 17O nuclear magnetic resonance during differentiation induced by dimethyl sulfoxide (Me2SO). While in noninduced cells water permeability was essentially constant during the growth period, in the Me2SO-induced cells there were two distinct periods at which the water permeability was increased by at least an order of magnitude. These periods correspond to approximately one doubling time and 6 days of growth. This change in water permeability is not due to direct interaction of Me2SO with the membrane but must be ascribed to structural changes in the membrane during the course of differentiation.