Open AccessHemoglobin ontogeny during normal mouse fetal development.
Author(s) -
Timothy W. Brotherton,
David H.K. Chui,
Jack Gauldie,
Michael M. Patterson
Publication year - 1979
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.76.6.2853
Subject(s) - ontogeny , yolk sac , fetus , hemoglobin , biology , gestation , fetal hemoglobin , embryogenesis , population , andrology , embryo , embryonic stem cell , microbiology and biotechnology , endocrinology , pregnancy , biochemistry , genetics , medicine , gene , environmental health
Pure populations of large, nucleated erythrocytes derived from yolk sac blood islands were obtained during normal fetal mouse development. Embryonic hemoglobins were present in these cells early in gestation. Later in gestation, an increasing amount of adults hemoglobin was also synthesized and accumulated in this population of primitive nucleated erythrocytes, as demonstrated by both biochemical and immunocytochemical techniques.