Sodium-induced calcium release from mitochondria in brown adipose tissue. | Zendy

MUTHANNA H. AL-SHAIKHALY | Zendy; Jan Nedergaard | Zendy; Barbara Can | Zendy

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Sodium-induced calcium release from mitochondria in brown adipose tissue.

Author(s) -

MUTHANNA H. AL-SHAIKHALY,

Jan Nedergaard,

Barbara Can

Publication year - 1979

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.76.5.2350

Subject(s) - ionophore , brown adipose tissue , monensin , calcium , adipose tissue , sodium , chemistry , mitochondrion , incubation , substrate (aquarium) , sodium iodide , endocrinology , choline , respiration , medicine , biophysics , biochemistry , biology , anatomy , ecology , organic chemistry

Coupled mitochondria of brown adipose tissue can accumulate Ca2+ if a substrate is present. The Ca2+ is released by addition of 20 mM Na+, but not by addition of K+ or choline +. Energy-dissipating Na+-induced Ca2+ cycling occurs maximally with 20 mM Na+ and 10 microM Ca2+. In brown adipocytes, the Ca2+ ionophore A23187 and the Na+ ionophore monensin increase respiration if substrate is added, and incubation in a low-Na+ buffer decreases norepinephrine-induced respiration. Thus Na+-induced Ca2+ release takes place in brown adipose tissue; released Ca2+ could have a regulatory or thermogenic role or both.

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