Amino acid sequence of ATP phosphoribosyltransferase of Salmonella typhimurium. | Zendy

Dennis Piszkiewicz | Zendy; Bill E. Tilley | Zendy; Tsafrira RandMeir | Zendy; Stanley M. Parsons | Zendy

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Amino acid sequence of ATP phosphoribosyltransferase of Salmonella typhimurium.

Author(s) -

Dennis Piszkiewicz,

Bill E. Tilley,

Tsafrira RandMeir,

Stanley M. Parsons

Publication year - 1979

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.76.4.1589

Subject(s) - biochemistry , peptide sequence , phosphoribosyltransferase , amino acid , biology , nucleic acid sequence , protein primary structure , cysteine , microbiology and biotechnology , chemistry , gene , enzyme , hypoxanthine guanine phosphoribosyltransferase , mutant

The amino acid sequence of ATP phosphoribosyltransferase [1-(5'-phosphoribosyl)-ATP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.17] of Salmonella typhimurium has been determined. The amino acid sequence analysis was carried out with a combination of manual and automated methods. It was complemented by DNA sequence analysis (done in another laboratory) of the hisG gene, which codes for it. The subunit polypeptide chain contains 299 amino acid residues and has a molecular weight of 33,216. The amino-terminal segment of the protein is relatively basic in character and has limited sequence homologies with the lac repressor and histidinol dehydrogenase. In addition, the protein contains a 40-residue segment that has 13 residues identical with the sequence surrounding the active-site cysteine of glyceraldehyde-3-phosphate dehydrogenase.

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