Open AccessDNA fragments of the Mus musculus beta globin haplotypes Hbbs and Hbbd.
Author(s) -
Steven Weaver,
Nancy L. Haigwood,
Clyde A. Hutchison,
Marshall H. Edgell
Publication year - 1979
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.76.3.1385
Subject(s) - haplotype , gene , biology , globin , genetics , beta (programming language) , dna , locus (genetics) , microbiology and biotechnology , genotype , computer science , programming language
Two alternative haplotypes at the complex locus controlling hemoglobin beta chain synthesis in Mus musculus were compared at the DNA level. As expected, Hbbd homozygotes--which as adults synthesize two species of beta chain--have two genes for beta globin. Adult mice homozygous for the Hbbs haplotype make only a single type of beta polypeptide, yet they also have two beta globin genes. Apparently the two Hbbs genes encode identical proteins, or one of the two genes is not detectably expressed. The Hbbs and Hbbd haplotypes are thus more similar at the DNA level than studies of their polypeptide products have indicated.