Open AccessAction of cathepsin D on human beta-lipotropin: a possible source of human "beta-melanotropin".
Author(s) -
Erzsébet Barát,
András Patthy,
László Gráf
Publication year - 1979
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.76.12.6120
Subject(s) - beta (programming language) , cathepsin d , chemistry , peptide , oligopeptide , endorphins , biochemistry , endocrinology , biology , enzyme , computer science , programming language
Highly purified calf brain cathepsin D (EC 3.4.23.5) selectively splits the Leu77-Phe78 and Ala36-Ala37 peptide bonds of human beta-lipotropin. It is suggested that the formation of human "beta-melanotropin" from gamma-lipotropin, and that of gamma-endorphin from beta-endorphin, is due to the action of cathepsin D during isolation procedures.