Open AccessRegulation of synthesis of a major outer membrane protein: cyclic AMP represses Escherichia coli protein III synthesis.
Author(s) -
Udo Mallick,
Peter Herrlich
Publication year - 1979
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.76.11.5520
Subject(s) - escherichia coli , effector , protein biosynthesis , chemistry , bacterial outer membrane , transcription (linguistics) , biochemistry , microbiology and biotechnology , biology , biophysics , gene , linguistics , philosophy
Cyclic AMP is the effector molecule for both positive and negative control of synthesis of several Escherichia coli proteins. Among the latter is the major outer membrane protein III. The control mechanism occurs at the level of transcription and involves the cyclic AMP receptor protein. The repressing system is saturated at lower concentrations of cyclic AMP than is the positive control system.