Open AccessStructure of the human G gamma-A gamma-delta-beta-globin gene locus.
Author(s) -
R. Bernards,
P.F.R. Little,
G. Annison,
Robert Williamson,
R.A. Flavell
Publication year - 1979
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.76.10.4827
Subject(s) - gene , bamhi , genetics , biology , microbiology and biotechnology , locus (genetics) , globin , beta (programming language) , dna , plasmid , computer science , programming language
We have constructed a physical map of the human G gamma-, A gamma-, delta-, and beta-globin genes. The previously described maps of the fetal and adult beta-like globin genes have been linked to one another by identification of a DNA fragment, generated by BamHI, that contains part of each of the A gamma- and delta-globin genes. The map obtained, which spans more than 40 kilobases, shows the following intergene distances: between G gamma and A gamma, 3500 base pairs; between A gamma and delta, 13,500 base pairs; and between delta and beta, 5500 base pairs. All genes are transcribed from the same DNA strand.