Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene. | Zendy

R Finberg | Zendy; H L Weiner | Zendy; B N Fields | Zendy; Baruj Benacerraf | Zendy; S J Burakoff | Zendy

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Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.

Author(s) -

R Finberg,

H L Weiner,

B N Fields,

Baruj Benacerraf,

S J Burakoff

Publication year - 1979

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.76.1.442

Subject(s) - cytotoxic t cell , biology , virology , tropism , cytolysis , ctl* , gene , effector , in vitro , microbiology and biotechnology , virus , immunology , genetics

Cytotoxic T lymphocytes (CTLs) can be generated if spleen cells from reovirus-infected mice are stimulated in vitro with syngeneic reovirus-infected cells. These cytolytic effector cells demonstrate: (i) serotype specificity (i.e., maximal cytolytic activity is observed on target cells infected with the serotype used to induce the CTLs) and (ii) H-2 restriction. The SI gene was shown to be the predominant viral gene determining the specificity of the cytotoxic T cells. This genome segment has previously been demonstrated to encode the viral hemagglutinin and determines reovirus cell tropism in the nervous system.

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