Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg. | Zendy

W.M. Generoso | Zendy; K.T. Cain | Zendy; M S Krishna | Zendy; Sandra W. Huff | Zendy

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Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.

Author(s) -

W.M. Generoso,

K.T. Cain,

M S Krishna,

Sandra W. Huff

Publication year - 1979

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.76.1.435

Subject(s) - ethyl methanesulfonate , dominant lethal , methyl methanesulfonate , biology , andrology , pyrene , isopropyl , mutagen , cleavage (geology) , microbiology and biotechnology , genetics , chemistry , dna , dna repair , gene , mutation , medicine , paleontology , organic chemistry , astrobiology , fracture (geology)

Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of first-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine, and benzo[a]pyrene treatments; and no difference was found for x-ray treatment.

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