Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium. | Zendy

T R Skopek | Zendy; Howard L. Liber | Zendy; Debra A. Kaden | Zendy; William G. Thilly | Zendy

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Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium.

Author(s) -

T R Skopek,

Howard L. Liber,

Debra A. Kaden,

William G. Thilly

Publication year - 1978

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.75.9.4465

Subject(s) - salmonella , frameshift mutation , auxotrophy , mutation , histidine , biology , reversion , genetics , microbiology and biotechnology , chemistry , gene , bacteria , escherichia coli , amino acid , phenotype

Forward mutation to 8-azaguanine resistance and reverse mutation to histidine prototrophy were measured in Salmonella typhimurium after treatment with 16 mutagens of both base-substitution and frameshift classes. The two approaches were found to be equisensitive for all 16 mutagens--i.e., induction of significant mutation occurred at similar concentrations in the forward mutation assay and in the most sensitive of the five Ames tester strains.

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