ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12. | Zendy

Thomas A. Bickle | Zendy; C. Brack | Zendy; R Yuan | Zendy

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ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12.

Author(s) -

Thomas A. Bickle,

C. Brack,

R Yuan

Publication year - 1978

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.75.7.3099

Subject(s) - escherichia coli , atp hydrolysis , conformational change , dna , restriction enzyme , cleavage (geology) , endonuclease , biochemistry , nucleotide , enzyme , chemistry , escherichia coli proteins , adenosine triphosphate , hydrolysis , biology , gene , paleontology , atpase , fracture (geology)

ATP induces a conformational change in the Escherichia coli K-12 restriction enzyme that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. However, ATP hydrolysis is a requirement for DNA cleavage.

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