Different time course of development for high-affinity choline uptake and choline acetyltransferase in the chick retina. | Zendy

C R Bader | Zendy; Robert P. Baughman | Zendy; J L Moore | Zendy

Open Access

Different time course of development for high-affinity choline uptake and choline acetyltransferase in the chick retina.

Author(s) -

C R Bader,

Robert P. Baughman,

J L Moore

Publication year - 1978

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.75.5.2525

Subject(s) - choline acetyltransferase , choline , acetylcholine , retina , enzyme , biochemistry , chemistry , acetyltransferase , biology , endocrinology , neuroscience , gene , acetylation

Synthesis and storage of [3H]acetylcholine in isolated pieces of chick retina increased in two stages during embryogenesis. The first increase coincided with a 100-fold rise in the activity of choline acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6), but during the second increase the activity of this enzyme remained essentially constant. The second increase instead was linked to an approximately 6-fold increase in the Vmax for high-affinity uptake of choline.

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