Open AccessKinetics of hemoglobin and transition state theory.
Author(s) -
Attila Szabó
Publication year - 1978
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.75.5.2108
Subject(s) - cooperativity , kinetics , hemoglobin , transition state theory , chemistry , transition (genetics) , thermodynamics , ligand (biochemistry) , computational chemistry , biochemistry , physics , reaction rate constant , receptor , quantum mechanics , gene
Experimental evidence indicates that the way cooperativity in hemoglobin is manifested kinetically depends on the nature of the ligand. It is shown that the qualitative differences in the kinetics of NO, O2, CO, and bulky isocyanides can be understood in structural terms in a framework based on transition state theory.