Open AccessIon flow through a membrane: effect of chemical reaction on time dependence.
Author(s) -
T. R. Hays,
S. H. Lin,
Henry Eyring
Publication year - 1978
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.75.5.2064
Subject(s) - equilibrium constant , chemistry , reaction rate constant , dissociation (chemistry) , ion , membrane , dissociation constant , dynamic equilibrium , relaxation (psychology) , time constant , constant (computer programming) , thermodynamics , kinetics , analytical chemistry (journal) , chromatography , organic chemistry , biochemistry , physics , biology , engineering , receptor , quantum mechanics , programming language , electrical engineering , computer science , neuroscience
The membrane model previously described [Hays, T.R., Buckwalter, C.Q., Lin S.H. & Eyring, H. (1978) Proc. Natl. Acad. Sci. USA 75, 1612-1615] for ion flow through a membrane is expanded to include the effect of binding of the mobile ion at the occupiable sites in the membrane. Two different effects were investigated: alteration of the association-dissociation rates at constant equilibrium constant and alteration of the equilibrium constant at constant dissociation constant. Increasing the rates of association and dissociation initially causes an increased slowing of the relaxation to the final steady state, though ultimately the curves for the faster rates cross those for the slower states. Increasing the equilibrium constant causes a greater delay in the relaxation curve, with the curves for different equilibrium constants not crossing. Overall, the effect of binding is not very great unless the equilibrium constant for binding is quite large.
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