Open AccessPlasma radioiron kinetics in man: explanation for the effect of plasma iron concentration.
Author(s) -
Karl Olof Skårberg,
Marlene Eng,
Helmut A. Huebers,
George Marsaglia,
Clement A. Finch
Publication year - 1978
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.75.3.1559
Subject(s) - transferrin , chemistry , kinetics , plasma , metabolism , endocrinology , medicine , plasma clearance , biochemistry , biology , pharmacokinetics , physics , quantum mechanics
The plasma iron turnover was measured in 19 normal subjects. A correlation was found between plasma iron concentration and plasma iron turnover. In addition to the turnover of 55Fe at normal plasma iron concentration (predominantly monoferric transferrin), a second turnover in which the labeled plasma was saturated with iron (to produce predominantly diferric transferrin) was studied with 50Fe. It was demonstrated that diferric transferrin had a greater rate of iron turnover but that the distribution between erythroid and non-erythroid tissues was unchanged. It was concluded that plasma iron turnover is dependent on the monoferric/diferric transferrin ratio in the plasma but that the internal distribution of iron is unaffected.