Open AccessCooperativity in O2 binding to iron porphyrins.
Author(s) -
James P. Collman,
John I. Brauman,
Éric Rose,
Kenneth S. Suslick
Publication year - 1978
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.75.3.1052
Subject(s) - cooperativity , chemistry , ferrous , steric effects , cooperative binding , diphosphoglycerate , hemoglobin , crystallography , binding site , stereochemistry , biochemistry , organic chemistry
The solid-gas O2 binding equilibrium has been studied for for ferrous "picket fence" porphyrinates with sterically hindered axial imidazoles. Such systems show significant cooperativity in their binding of O2: at low O2 pressures a low O2 affinity form exists, and at high O2 pressures a higher O2 affinity form develops. Direct analogies are drawn to the cooperativity shown in O2 binding by hemoglobin. These model systems mimic hemoglobin quantitatively.