Open AccessProduction a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum.
Author(s) -
Denis Gospodarowicz,
Kewal K. Thakral
Publication year - 1978
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.75.2.847
Subject(s) - corpus luteum , neovascularization , ovary , vascular endothelial growth factor , biology , angiogenesis , medicine , corneal neovascularization , endocrinology , vegf receptors
Factors controlling the changes in the vascular pattern of the ovary that occur during the reproductive cycle have been investigated. By using the rabbit cornea, the abilities of ovarian corpus luteum and of follicles to induce neovascularization have been compared. While the corpus luteum is capable of inducing neovascularization, the follicles do not have this ability. It is therefore likely that the corpus luteum actively participates in its own neovascularization by secreting a factor that we have called "corpus leutem angiogenic factor" (CLAF).