Open AccessPrimary structure of human C-reactive protein.
Author(s) -
Eduardo B. Oliveira,
Emil C. Gotschlich,
TehYung Liu
Publication year - 1977
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.74.8.3148
Subject(s) - homology (biology) , protein primary structure , sequence homology , peptide sequence , biology , antibody , amino acid residue , homology modeling , amino acid , chemistry , microbiology and biotechnology , biochemistry , genetics , gene , enzyme
The complete amino acid sequence of human C-reactive protein has been established. Distant homologies to C3 homology region in the CH2 domain of IgG and to C3a anaphylotoxin have been noted. No homology to other immunoglobulin homology regions or to the same homology region in other heavy chains was observed. The previously reported homologies between rabbit and human C-reactive protein and protein C1t have been extended and strengthened.