Open AccessThe complete amino acid sequence of prochymosin.
Author(s) -
Bent Foltmann,
Vibeke Barkholt Pedersen,
Henning Jacobsen,
Dorothy L. Kauffman,
Grith B. Wybrandt
Publication year - 1977
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.74.6.2321
Subject(s) - proteases , peptide sequence , amino acid , amino acid residue , sequence (biology) , biochemistry , sequence alignment , biology , pepsin , multiple sequence alignment , enzyme , chemistry , gene
The total sequence of 365 amino acid residues in bovine prochymosin is presented. Alignment with the amino acid sequence of porcine pepsinogen shows that 204 amino acid residues are common to the two zymogens. Further comparison and alignment with the amino acid sequence of penicillopepsin shows that 66 residues are located at identical positions in all three proteases. The three enzymes belong to a large group of proteases with two aspartate residues in the active center. This group forms a family derived from one common ancestor.