Inactivation and proteolytic cleavage of phage lambda repressor in vitro in an ATP-dependent reaction. | Zendy

Jeffrey W. Roberts | Zendy; Charles W.M. Roberts | Zendy; David W. Mount | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inactivation and proteolytic cleavage of phage lambda repressor in vitro in an ATP-dependent reaction.

Author(s) -

Jeffrey W. Roberts,

Charles W.M. Roberts,

David W. Mount

Publication year - 1977

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.74.6.2283

Subject(s) - repressor , lysogen , lambda phage , cleavage (geology) , bacteriophage , divalent , in vitro , biology , dna , microbiology and biotechnology , in vivo , biochemistry , chemistry , escherichia coli , gene , genetics , gene expression , paleontology , organic chemistry , fracture (geology)

We have reproduced in vitro the inactivation of bacteriophage lambda repressor that occurs in vivo when a lambda lysogen is treated with agents such as ultraviolet radiation that attack DNA. ATP and a divalent cation are required for the inactivation reaction. The ind- repressor is insensitive to the inactivation mechanism. A proteolytic cleavage of repressor accompanies inactivation in vitro, as it does in vivo.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research