Open Access5'-deoxypyridoxal as a potential anti-sickling agent.
Author(s) -
Ruth E. Benesch,
Ruth E. Benesch,
Rohinton Edalji,
Tomokazu Suzuki
Publication year - 1977
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.74.4.1721
Subject(s) - hemoglobin , oxygen , chemistry , cell , p50 , biochemistry , red cell , hemoglobin s , sickle cell anemia , medicine , organic chemistry , gene , transcription factor
5'-Deoxypyridoxal, which reacts specifically with the terminal amino groups of the alpha chains of hemoglobin, increases the oxygen affinity of hemoglobin solutions as well as of dilute suspensions of normal and sickle red cells and whole blood. As a result, the proportion of deoxyhemoglobin (which is responsible for sickling) is decreased at venous oxygen tensions and this is reflected by a sharply reduced sickle cell count in this range of oxygen pressures.