Translation of melittin messenger RNA in vitro yields a product terminating with glutaminylglycine rather than with glutaminamide. | Zendy

Gerda Suchanek | Zendy; G. Kreil | Zendy

Open Access

Translation of melittin messenger RNA in vitro yields a product terminating with glutaminylglycine rather than with glutaminamide.

Author(s) -

Gerda Suchanek,

G. Kreil

Publication year - 1977

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.74.3.975

Subject(s) - melittin , messenger rna , rna , translation (biology) , bee venom , chemistry , in vitro , biochemistry , biology , peptide , gene , zoology

Melittin messenger RNA from queen bee venom glands has been translated in a cell-free system from wheat germ. A product larger than promelittin is formed which has the carboxy-terminal sequence-Gln-Gln-GlyCOOH. Melittin and promelittin from venom glands terminate in -Gln-GlnCONH2. The possible role of the extra glycine residue in the formation of a COOH-terminal amide via a transamidase-like reaction is discussed.

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