Granulocyte collagenase: selective digestion of type I relative to type III collagen. | Zendy

Allen L. Horwitz | Zendy; A J Hance | Zendy; Ronald G. Crystal | Zendy

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Granulocyte collagenase: selective digestion of type I relative to type III collagen.

Author(s) -

Allen L. Horwitz,

A J Hance,

Ronald G. Crystal

Publication year - 1977

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.74.3.897

Subject(s) - collagenase , fibroblast , type i collagen , proteolysis , connective tissue , microbial collagenase , collagen, type i, alpha 1 , chemistry , granulocyte , microbiology and biotechnology , inflammation , immunology , biochemistry , biology , pathology , enzyme , extracellular matrix , in vitro , endocrinology , medicine

Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.

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