Open AccessGenetic control of mitochondrial malate dehydrogenases: evidence for duplicated chromosome segments.
Author(s) -
NingSun Yang,
John C. Sorenson,
John G. Scandalios
Publication year - 1977
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.74.1.310
Subject(s) - malate dehydrogenase , biology , isozyme , genetics , gene duplication , gene , mitochondrial dna , mitochondrion , chromosome , nad+ kinase , oxidoreductase , biochemistry , microbiology and biotechnology , enzyme
The genetic control of the major mitochondrial isoenzymes of malate dehydrogenase (L-malate:NAD+ oxidoreductase; EC 1.1.1.37) has been investigated in Zea mays. The mitochondrial isozymes are coded at four nuclear gene loci. Two of the loci (mdh1 and mdh2) are diallelic and tightly linked. The other two loci (mdh3 and mdh4) appear to have arisen by duplication of the chromosome segment carrying mdh1 and mdh2, but are not linked to them. The segregation of such a duplicate segment can explain anomalous backcross and F2 segregation ratios.