Open AccessOpioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.
Author(s) -
Brian M. Cox,
Avram Goldstein,
Chernov Hi
Publication year - 1976
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.73.6.1821
Subject(s) - peptide , beta (programming language) , chemistry , endorphins , beta endorphin , enkephalin , opioid peptide , receptor , opiate , ileum , endocrinology , opioid , medicine , pharmacology , biochemistry , biology , computer science , programming language
The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.