Superinfection epithelial nasopharyngeal carcinoma cells with Epstein-Barr virus. | Zendy

Ronald Glaser | Zendy; Guy de Thé | Zendy; G Lenoir | Zendy; J. H. C. Ho | Zendy

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Superinfection epithelial nasopharyngeal carcinoma cells with Epstein-Barr virus.

Author(s) -

Ronald Glaser,

Guy de Thé,

G Lenoir,

J. H. C. Ho

Publication year - 1976

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.73.3.960

Subject(s) - nasopharyngeal carcinoma , virus , epstein–barr virus , superinfection , biology , virology , explant culture , cell culture , antigen , herpesviridae , cell , immunology , in vitro , viral disease , medicine , biochemistry , genetics , radiation therapy

Attempts were made to superinfect epithelial explant cell cultures prepared from nasopharyngeal carcinomas with Epstein-Barr virus. Virus-specific markers were observed in such cultures 3 days after superinfection. In addition, expression of Epstein-Barr virus early antigens was observed in epithelial cell explant cultures treated with iododeoxyuridine. The results suggest that epithelial cells of at least certain nasopharyngeal carcinomas possess the receptor for the Epstein-Barr virus and that the latent virus genome can be induced from epithelial cells prepared from such tumors.

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