Open AccessSuperinfection epithelial nasopharyngeal carcinoma cells with Epstein-Barr virus.
Author(s) -
Ronald Glaser,
Guy de Thé,
G Lenoir,
J. H. C. Ho
Publication year - 1976
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.73.3.960
Subject(s) - nasopharyngeal carcinoma , virus , epstein–barr virus , superinfection , biology , virology , explant culture , cell culture , antigen , herpesviridae , cell , immunology , in vitro , viral disease , medicine , biochemistry , genetics , radiation therapy
Attempts were made to superinfect epithelial explant cell cultures prepared from nasopharyngeal carcinomas with Epstein-Barr virus. Virus-specific markers were observed in such cultures 3 days after superinfection. In addition, expression of Epstein-Barr virus early antigens was observed in epithelial cell explant cultures treated with iododeoxyuridine. The results suggest that epithelial cells of at least certain nasopharyngeal carcinomas possess the receptor for the Epstein-Barr virus and that the latent virus genome can be induced from epithelial cells prepared from such tumors.