Open AccessHeat mutagenesis in bacteriophage T4: the transversion pathway.
Author(s) -
P. M. Bingham,
Richard H. Baltz,
L. S. Ripley,
John W. Drake
Publication year - 1976
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.73.11.4159
Subject(s) - guanine , transversion , bacteriophage , glycosidic bond , mutagenesis , deoxyguanosine , base pair , transition (genetics) , biology , dna , chemistry , biochemistry , genetics , nucleotide , mutation , escherichia coli , gene , enzyme
Heat induces transversions (as well as transitions) at G-C base pairs in bacteriophage T4. The target base for transversions is guanine,which is converted to a product which is sometimes replicated and transcribed as a pyrimidine.A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G-C leads to C-G transversions.