Binding of autologous erythrocytes to immature T-cells. | Zendy

J Charreire | Zendy; J F Bach | Zendy

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Binding of autologous erythrocytes to immature T-cells.

Author(s) -

J Charreire,

J F Bach

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.8.3201

Subject(s) - thymectomy , rosette (schizont appearance) , spleen , rosette formation , biology , cell , immunology , microbiology and biotechnology , andrology , medicine , antibody , biochemistry , myasthenia gravis

A small percentage of normal mouse thymus and spleen lymphocytes form rosettes with autologous erythrocytes. The number of these autologous rosettes increases 15- to 20-fold after adult thymectomy and to a lesser degree with aging. Autologous rosette level is also abnormally high in nude (congenitally athymic) mice. The high level of autologous rosette-forming cells found after adult thymectomy is normalized by injecting ng amounts of purified circulating thymic factor. Autologous rosette-forming cells adhere to nylon, belong to the less dense spleen cells, are in majority steroid-resistant in the thymus. All these properties suggest that autologous rosette-forming cells might belong to immature T-cell (thymic-dependent cell) precursors.

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