Cleavage of adenovirus messenger RNA and of 28S and 18S ribosomal RNA by RNase III. | Zendy

H Westphal | Zendy; Robert J. Crouch | Zendy

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Cleavage of adenovirus messenger RNA and of 28S and 18S ribosomal RNA by RNase III.

Author(s) -

H Westphal,

Robert J. Crouch

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.8.3077

Subject(s) - degradosome , rna , rnase h , five prime cap , rnase p , microbiology and biotechnology , rnase mrp , post transcriptional modification , ribonuclease , messenger rna , ribosomal rna , nuclease protection assay , biology , rna dependent rna polymerase , ribonuclease iii , biochemistry , gene , rna interference

Escherichia coli ribonuclease III cleaves adenovirus messenger RNA and mammalian 28S and 18S ribosomal RNA. Fragmentation is not random, but in each case a specific collection of products is generated. This points to the potential use of the enzyme as a tool for specific fragmentation of RNA. Cleavage by RNase III abolishes the capability of adenovirus messenger RNA to direct cell-free synthesis of virus polypeptides.

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