Open AccessMinimal requirements for template recognition by bacteriophage Qβ replicase: Approach to general RNA-dependent RNA synthesis
Author(s) -
B. O. Küppers,
Manfred Sumper
Publication year - 1975
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.72.7.2640
Subject(s) - rna , rna dependent rna polymerase , polynucleotide , bacteriophage , sequence (biology) , computational biology , biology , chemistry , biochemistry , gene , escherichia coli
Any oligo- or polynucleotide able to offer a C-C-C-sequence at the 3′-terminus and a second C-C-C-sequence in a defined steric position to Qβ replicase is an efficient template. Corresponding chemical modifications convert non-template RNAs to template RNAs.
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