An octamer of histones in chromatin and free in solution. | Zendy

Jean Thomas | Zendy; Roger D. Kornberg | Zendy

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An octamer of histones in chromatin and free in solution.

Author(s) -

Jean Thomas,

Roger D. Kornberg

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.7.2626

Subject(s) - histone octamer , histone , chromatin , chemistry , dissociation (chemistry) , ionic strength , biophysics , nucleosome , biochemistry , crystallography , biology , dna , aqueous solution

Crosslinking with dimethyl suberimidate reveals a chain of histone octamers in chromatin. The octamer can be isolated free in solution at high ionic strength and pH. The identification of dimers formed by crosslinking reveals two or more contacts of each histone with others within the octamer. The molecular weight (110,000) and pattern of dissociation of the octamer are compatible with the composition (F2A1)2(F3)2(F2A2)2(F2B)2.

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