Homology and relationship between the genomes of papovaviruses, BK virus and simian virus 40. | Zendy

George Khoury | Zendy; Peter M. Howley | Zendy; Claude F. Garon | Zendy; Michael Mullarkey | Zendy; K. K. Takemoto | Zendy; Miguel Martı́n | Zendy

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Homology and relationship between the genomes of papovaviruses, BK virus and simian virus 40.

Author(s) -

George Khoury,

Peter M. Howley,

Claude F. Garon,

Michael Mullarkey,

K. K. Takemoto,

Miguel Martı́n

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.7.2563

Subject(s) - genome , bk virus , simian , biology , sequence homology , homology (biology) , virus , virology , homologous chromosome , genetics , gene , peptide sequence , kidney transplantation , kidney

A number of hybridization techniques have been used to assess the homology between the genomes of BK virus (BKV) and simian virus 40 (SV40). A noncontiguous set of homologous sequences has been localized primarily within the late region of the SV40 genome, and these sequences presumably account for the cross-reaction between V-antigens of the two viruses. The reason for the relatively strong crossreaction between SV40 and BKV T-antigens is still unclear. The sequence homology and similarity in genomic organization suggest a close relationship between these papovaviruses.

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