Open AccessHomology and relationship between the genomes of papovaviruses, BK virus and simian virus 40.
Author(s) -
George Khoury,
Peter M. Howley,
Claude F. Garon,
Michael F. Mullarkey,
Kenneth K. Takemoto,
Malcolm A. Martin
Publication year - 1975
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.72.7.2563
Subject(s) - genome , bk virus , simian , biology , sequence homology , homology (biology) , virus , virology , homologous chromosome , genetics , gene , peptide sequence , kidney transplantation , kidney
A number of hybridization techniques have been used to assess the homology between the genomes of BK virus (BKV) and simian virus 40 (SV40). A noncontiguous set of homologous sequences has been localized primarily within the late region of the SV40 genome, and these sequences presumably account for the cross-reaction between V-antigens of the two viruses. The reason for the relatively strong crossreaction between SV40 and BKV T-antigens is still unclear. The sequence homology and similarity in genomic organization suggest a close relationship between these papovaviruses.