Antigen mobility in membranes and complement-medical immune attack. | Zendy

G M Humphires | Zendy; Harden M. McConnell | Zendy

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Antigen mobility in membranes and complement-medical immune attack.

Author(s) -

G M Humphires,

Harden M. McConnell

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.7.2483

Subject(s) - cardiolipin , dipalmitoylphosphatidylcholine , complement fixation test , chemistry , cholesterol , membrane , liposome , complement system , antigen , phospholipid , immune system , antibody , biochemistry , biophysics , biology , immunology , phosphatidylcholine , serology

The complement fixing activity of liposomes containing cholesterol, dimyristoylphosphatidylcholine (or dipalmitoylphosphatidylcholine), and 3 mol % of cardiolipin has been studied as a function of cholesterol concentration by use of human syphilitic serum containing cardiolipin-specific (Wasserman) antibodies. It is found that complement fixation increases rapidly for cholesterol concentrations above 35 mol %. Spin label studies have been used to study the incorporation of cardiolipin in the relatively rigid phase of binary mixtures of cholesterol and dimyristolphosphatidycholine (or dipalmitoylphosphatidylcholine). It is concluded that cardiolipin is included in such a phase of these lipids for cholesterol concentrations above 35 mol %. These results indicate that a relatively rigid lateral distribution of this monovalent antigen in the plane of the membrane facilitates complement fixation and concomitant complement-mediated membrane damage.

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