Lymphokine-induced production and release of lysosomal enzymes by macrophages. | Zendy

R M Pantalone | Zendy; Roy C. Page | Zendy

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Lymphokine-induced production and release of lysosomal enzymes by macrophages.

Author(s) -

R M Pantalone,

Roy C. Page

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.6.2091

Subject(s) - lymphokine , enzyme , connective tissue , macrophage , liberation , peripheral blood mononuclear cell , biochemistry , chemistry , biology , immunology , in vitro , genetics

MACROPHAGES ARE ASSOCIATED WITH MOST CHRONIC INFLAMMATORY LESIONS, AND THESE CELLS CONTAIN ENZYMES THAT ARE ABLE TO DESTROY CONNECTIVE TISSUE CONSTITUENTS. Normal lymphoid cells responding to a mitogen, phytohemagglutinin-P, release factor(s) that cause a marked increase in the size and enzyme content for mononuclear phagocytes maintained in culture. The stimulated macrophages, which by several criteria remain otherwise viable and healthy, selectively release large quantities of hydrolytic enzymes to the culture medium.

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