Open AccessA link between streptomycin and rifampicin mutation.
Author(s) -
Sankar Lal Chakrabarti,
Luigi Gorini
Publication year - 1975
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.72.6.2084
Subject(s) - biology , transcription (linguistics) , genetics , rna polymerase , bacteriophage , t7 rna polymerase , mutation , permissiveness , permissive , ribosome , escherichia coli , microbiology and biotechnology , reversion , rna , gene , viral replication , virus , phenotype , philosophy , linguistics
of str A mutations frequently make "male" strains of Escherichia coli permissive to bacteriophage T7; certain rif mutations reverse the permissive effect of strA mutation. Permissiveness of the strA mutation is accompanied by enhanced transcription of bacteriophage T7 genome. Introduction of the nonpermissive rif allele to the permissive strA strain reduces or abolishes the transcription of T7 genome. Thus, a link is implied in the functioning of the ribosome and the RNA polymerase (RNA nucleotidyltransferase, EC 2.7.7.6).