Preferential and cooperative binding of histone I to chromosomal mammalian DNA. | Zendy

Manfred Renz | Zendy

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Preferential and cooperative binding of histone I to chromosomal mammalian DNA.

Author(s) -

Manfred Renz

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.2.733

Subject(s) - histone , dna , microbiology and biotechnology , chemistry , escherichia coli , binding site , biology , biochemistry , gene

There is a strong preferential binding of histone I to lymphocyte DNA as compared to Escherichia coli DNA when large DNA fragments (2 times 10-6 daltons) are used. The binding of histone I to lymphocyte DNA and to E. coli DNA is cooperative. The distribution of preferential binding sites has been investigated on fragmented DNA. Most of the 2 times 10-6 dalton fragments were found to have at least one preferential histone I binding site, whereas most of the 2 times 10-5 dalton fragments have none.

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