A very rapid effect of androgen on initiation of protein synthesis in prostate. | Zendy

Tuo Liang | Zendy; SihHan Liao | Zendy

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A very rapid effect of androgen on initiation of protein synthesis in prostate.

Author(s) -

Tuo Liang,

SihHan Liao

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.2.706

Subject(s) - cytosol , ribosome , dihydrotestosterone , gtp' , ribosomal rna , prostate , chemistry , protein biosynthesis , eukaryotic small ribosomal subunit , androgen , medicine , endocrinology , protein subunit , biology , biochemistry , hormone , enzyme , rna , cancer , gene

The initiation of protein synthesis by ribosomal particles of rat ventral prostate was studied by measuring ribosomal binding of an initiator (35-S)methionyl-tRNAf. The binding activity is dependent on ribosomes, GTP, and a prostate cytosol protein fraction. The 40S but not the 60S ribosomal subunit particles are active. The cytosol activity decreases rapidly within one hour after the rat is castrated. This loss is prevented by an intraperitoneal injection of 17beta-hydroxy-5-alpha-androstan-3-one (5-alpha-dihydrotestosterone). The cytosol activity can be stimulated almost immediately (within 10 min) after an intravenous injection of low dose (15 mug per rat) of 5-alpha-dihydrotestosterone into the castrated rat.

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