Biosynthesis of ribosylthymine in the transfer RNA of Streptococcus faecalis: a folate-dependent methylation not involving S-adenosylmethionine. | Zendy

Ann S. Delk | Zendy; Jesse C. Rabinowitz | Zendy

Open Access

Biosynthesis of ribosylthymine in the transfer RNA of Streptococcus faecalis: a folate-dependent methylation not involving S-adenosylmethionine.

Author(s) -

Ann S. Delk,

Jesse C. Rabinowitz

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.2.528

Subject(s) - methylation , transfer rna , biochemistry , moiety , rna , streptococcus , chemistry , biosynthesis , residue (chemistry) , methyltransferase , biology , bacteria , stereochemistry , gene , genetics

Ribosylthymine is not present in tRNA of Streptococcus faecalis grown in the absence of folic acid, although this methylated residue does occur in the tRNA of this organism when it is grown in the presence of folate. We have found that, unlike other methylated residues in RNA of S. faecalis and other organisms, the methyl moiety of ribosylthymine of the tRNA of folate-sufficient S. faecalis is not derived from S-adenosylmethionine. Preliminary evidence suggests that a folate derivative serves as the methyl donor in this methylation.

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