Murine leukemia virus: detection of unintegrated double-stranded DNA forms of the provirus. | Zendy

AM Gianni | Zendy; David Smotkin | Zendy; R A Weinberg | Zendy

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Murine leukemia virus: detection of unintegrated double-stranded DNA forms of the provirus.

Author(s) -

AM Gianni,

David Smotkin,

R A Weinberg

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.2.447

Subject(s) - provirus , dna , microbiology and biotechnology , virus , virology , biology , murine leukemia virus , leukemia , genome , gene , genetics

Infection of JLS V-9 (mouse bone marrow) cells with Moloney murine leukemia virus leads to appearance of virus-specific DNA in the low molecular weight DNA fraction from infected cells. Most of this DNA is double-stranded. Two discrete forms of double-stranded DNA, both of molecular weight 6 times 10-6, have been characterized. One of these forms is closed-circular, supercoiled DNA; the other form is a mixture of nicked-circular and linear DNA.

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