Open AccessH-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.
Author(s) -
J. F. A. P. Miller,
Mathew A. Vadas,
Alison Whitelaw,
Jennifer R. Gamble
Publication year - 1975
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.72.12.5095
Subject(s) - homing (biology) , antigen , gene , gene transfer , delayed hypersensitivity , immunology , chemistry , microbiology and biotechnology , biology , genetics , ecology
Sensitized lymphocytes can transfer a state of delayed-type hypersensitivity to soluble protein antigens to naive mice only if donor and recipient share the I-A region of the H-2 gene complex. Identity at the K or D region is not essential. The restriction is unlikely to result from ineffective homing of the injected cells or from their early destruction. It is thought to reflect a requirement for an Ir-gene controlled mechanism which governs effective interaction between sensitized T lymphocytes and antigen presented on the surface of macrophages.