Open AccessX-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA.
Author(s) -
Peter J. Bond,
Robert Langridge,
K. W. Jennette,
Stephen J. Lippard
Publication year - 1975
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.72.12.4825
Subject(s) - fiber diffraction , platinum , intercalation (chemistry) , crystallography , diffraction , dna , x ray , x ray crystallography , chemistry , materials science , biochemistry , inorganic chemistry , physics , optics , catalysis
Good quality x-ray diffraction patterns have been obtained of polycrystalline fibers containing 2-hydroxyethanethiolato(2,2'2"-terpyridine)platinum(II) bound to calf thymus DNA by intercalation. The photographs strongly support the neighbor exclusion binding model in which electron-dense platinum atoms are regularly distributed at 10.2 A intervals, every other interbase pair site.
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