Open AccessOrganization of Immunoglobulin Genes: Reiteration Frequency of the Mouse κ Chain Constant Region Gene
Author(s) -
Tasuku Honjo,
Seymour Packman,
David C. Swan,
Marion M. Nau,
Philip Leder
Publication year - 1974
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.71.9.3659
Subject(s) - gene , biology , genetics , immunoglobulin gene , dna , genome , antibody , immunoglobulin light chain , microbiology and biotechnology
Hybridization kinetic analyses with synthetic DNA indicate that there are only two to three copies of the κ constant region gene per haploid genome. This result lends weight to the argument that the immunoglobulin light chain is encoded by more than one continuous gene sequence.