A Ca ++ -Dependent and -Selective Ionophore as Part of the Ca ++ + Mg ++ -Dependent Adenosinetriphosphatase of Sarcoplasmic Reticulum | Zendy

Adil E. Shamoo | Zendy; David H. MacLennan | Zendy

Open Access

A Ca ⁺⁺ -Dependent and -Selective Ionophore as Part of the Ca ⁺⁺ + Mg ⁺⁺ -Dependent Adenosinetriphosphatase of Sarcoplasmic Reticulum

Author(s) -

Adil E. Shamoo,

David H. MacLennan

Publication year - 1974

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.71.9.3522

Subject(s) - ionophore , endoplasmic reticulum , calcium , isotopes of calcium , chemistry , atpase , biophysics , biochemistry , biology , enzyme , organic chemistry

Solubilized Ca Mg++ -dependent adenosinetriphosphatase (EC 3.6.1.3; ATP diphosphohydrolase) from sarcoplasmic reticulum increased bimolecular lipid membrane (oxidized cholesterol) conductance several hundred-fold. The relative conductance change and the relative permeability elicited by this material has the following sequence: Ba++ > Ca++ > Sr++ > Mg++ > Mn++ > Zn++ , Na+ , K+ , Cs+ , Li+ , and Rb+ . Zn++ and Na+ strongly inhibit the increase in Ca++ conductance obtained with solubilized Ca Mg++ -dependent adenosinetriphosphatase. The Ca++ -ionophore is an integral part of the Ca Mg++ -dependent adenosinetriphosphatase enzyme and may function as a Ca++ -carrier in the overall Ca++ -pump of sarcoplasmic reticulum.

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